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. 2008 Feb 6;105(6):2163–2168. doi: 10.1073/pnas.0711839105

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© 2008 by The National Academy of Sciences of the USA

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Fig. 4. — Regulation of 5-HT_1BR protein and p11 protein in unilaterally 6-OHDA-lesioned rats treated with saline, l-DOPA, or SCH23390 alone or in combination. (a) Western blots of 5-HT_1BR, p11, TH, and actin in unilaterally 6-OHDA-lesioned rats treated with saline, 100 mg/kg l-DOPA (i.p., twice daily), or 0.5 mg/kg SCH23390 (i.p., twice daily) alone or in combination for 5 days. Note the near-complete absence of TH in the 6-OHDA-lesioned hemispheres. (b and c) Quantification of striatal 5-HT_1BR (b) and p11 levels (c) normalized to actin. Filled bars, intact hemisphere; open bars, 6-OHDA-lesioned hemisphere. Data represent means ± SEM for 4–10 animals per group. *, P < 0.05; **, P < 0.01; ***, P < 0.001 between indicated treatments; one-way ANOVA followed by Newman–Keuls test.