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. 2008 Feb 11;105(6):2193–2197. doi: 10.1073/pnas.0711891105

Fig. 4.

Fig. 4.

Reversion of antihypernociceptive phenotype of GF (open bars) mice compared with CV (filled bars) ones. (A) Two weeks after feces administration (10 mg/kg; by oral gavage) from conventional or germ-free mice, mechanical hypernociception induced by i.pl. injection carrageenan (100 μg per paw) was evaluated in GF mice and compared with CV and GF vehicle-treated. (B) Then, 48 h after systemic LPS administration (1 mg/kg; s.c.), mechanical hypernociception induced by i.pl. injection of carrageenan (100 μg per paw) was evaluated in GF mice and compared with CV and GF vehicle-treated. The hypernociceptive responses were taken 3 h after carrageenan injection. The results are expressed by the mean ± SEM of at least five animals per group. Asterisks denote statistically significant differences compared with the control group (P < 0.05).