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. 2008 Aug 5;4:210. doi: 10.1038/msb.2008.48

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Copyright © 2008, EMBO and Nature Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.

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The fraction of Y2H interactions from the full set of Ito et al (2001) confirmed in a curated set of biologically functional interactions that were independently reported in two or more publications not using the Y2H technique. The x and y axis are the in vivo protein concentrations (Ghaemmaghami et al, 2003) in yeast cytoplasm. One can see that Y2H interactions between proteins with relatively high in vivo concentrations (>0.1 μM) have considerably higher chances of being biologically functional.