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. 2008 Aug 5;4:214. doi: 10.1038/msb.2008.50

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Copyright © 2008, EMBO and Nature Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation or the creation of derivative works without specific permission.

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Correlation between fasting insulin and 2-h metabolite changes in individuals with impaired glucose tolerance (FOS-IGT). (A) 2-h changes in markers of insulin action are correlated with fasting insulin concentration. Each dot corresponds to an individual. (B) A bivariate model explaining fasting insulin using the 2-h decline of Leu/Ile and glycerol. Each circle represents an individual, and the circle size is proportionate to fasting insulin levels. ^aA representative individual exhibiting a blunted decline in Leu/Ile (resistant to proteolysis suppression). ^bA representative individual exhibiting a blunted decline in glycerol (resistant to lipolysis suppression).