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Parameters related to the stochastic activity of DHPR and RyR channels
| Control | BayK 8644 | |||
|---|---|---|---|---|
| Prepulse (ms) | 1.5 | 5 | 1.5 | 5 |
| DHPR nPO | 4.8 ± 1.2 | 8.0 ± 2.0 | 6.8 ± 1.7 | 9.4 ± 2.4 |
| Control | BayK 8644 | |
|---|---|---|
| DHPR τO (ms) | 0.52 ± 0.07 | 1.35a |
| RyR τact (ms) | 0.62 ± 0.05 | 1.16 ± 0.12 |
| PCpl | 0.15 ± 0.03 | 0.24 ± 0.03 |
In the presence of BayK 8644, τO was fixed at the value determined directly from the time constant of ICa deactivation at −120 mV (Fig. 3A).
