TABLE 2.

Summary of substudies

Substudy	Objectives
Homocysteine Lowering and Atherosclerosis Reduction Trial (HART)	To evaluate the effects of the study intervention on atherosclerosis progression, evaluated by quantitative carotid ultrasonography
Status of Mental Examination (SOME)	To evaluate effects of the study intervention on cognitive function
Dietary Micronutrient Evaluation Substudy	To evaluate micronutrient intake in the Heart Outcomes Prevention Evaluation (HOPE)-2 study regions with and without folate food fortification policies and to study potential interactions between dietary micronutrient intake and the effects of the study intervention
Homocysteine Lowering Therapy and Venous Thromboembolism	To evaluate effects of the study intervention on deep vein thrombosis and pulmonary embolism
Homocysteine Lowering Therapy and Fractures	To evaluate the effects of the study intervention on vertebral and nonvertebral fractures
Studies of Novel Biochemical Risk Factors and Markers	Collection of baseline and follow-up blood samples for analysis of novel cardiovascular risk factors and markers