TABLE 2.
Multivariate analysis illustrating the independent associations of baseline risk, the number of coexisting conditions, age and hospital arrival times with the likelihood of receiving acute reperfusion therapy among ideal candidates*
| Adjusted OR | 95% CI | P | |
|---|---|---|---|
| Age (per year increase) | 0.99 | 0.97–1.00 | <0.001 |
| Hospital arrival times | 0.06 | ||
| <60 min | 1.00 | Reference | |
| 1 h to 2 h | 0.94 | 0.63–1.31 | |
| 3 h to 5 h | 0.70 | 0.46–1.04 | |
| 6 h to 9 h | 0.63 | 0.35–1.14 | |
| 10 h to 12 h | 0.33 | 0.14–0.75 | |
| Number of pre-existing cardiac-specific conditions† | <0.001 | ||
| No conditions | 1.00 | Reference | |
| One condition or more | 0.60 | 0.44–0.81 | |
| Number of pre-existing noncardiac conditions‡ | <0.001 | ||
| None or one condition | 1.00 | Reference | |
| Two conditions | 0.77 | 0.53–1.08 | |
| Three conditions or more | 0.60 | 0.42–0.85 | |
| Number of cumulative pre-existing conditions§ | <0.001 | ||
| None or one condition | 1.00 | Reference | |
| Two conditions | 0.95 | 0.63–1.41 | |
| Three conditions or more | 0.53 | 0.37–0.74 | |
| Baseline risk¶ | 0.96 | 0.92–1.00 | 0.04 |
Patients presenting with ST segment elevation acute myocardial infarction within 12 h of symptom onset with no absolute contraindications or refusal for therapy. Analyses adjusted for age, sex, income, ethnicity, hospital arrival times, baseline risk, number of pre-existing conditions, hospital characteristics (ie, on-site revascularization facilities) and geographical residents (rural-urban). The effects of sex, income, ethnicity, hospital characteristics and rural-urban status are P>0.1 for each, and are therefore not presented in the above model;
Pre-existing cardiac-specific conditions include pre-existing angina, previous myocardial infarction, previous congestive heart failure, previous percutaneous transluminal coronary angioplasty and previous coronary artery bypass graft;
Pre-existing noncardiac conditions include diabetes, hyperlipidemia, hypertension, smoking history, chronic obstructive pulmonary disease, asthma, depression, dementia, stroke, transient ischemic attack, other central nervous system disorders, cancer (metastatic), cholestasis, chronic liver disease, dialysis, renal insufficiency (140 mmol/L or greater), bilateral renal artery stenosis, coagulopathy/anemia, peptic ulcer disease, peripheral artery disease and thyroid disorders;
Cumulative number of pre-existing conditions includes pre-existing cardiac-specific and noncardiac conditions;
Baseline risk was derived using a risk-adjustment index from Morrow et al (22)