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. Author manuscript; available in PMC: 2008 Nov 29.

Published in final edited form as: J Med Chem. 2007 Oct 30;50(24):6080–6094. doi: 10.1021/jm070905o

Table 1.


Compound, R =	K_I^app (μM)^a	MIC₉₉ (μM)^b (iron-deficient)	MIC₉₉ (μM)^c (iron-rich)	Compound, R =	K_I^app (μM)^a	MIC₉₉ (μM)^b (iron-deficient)	MIC₉₉ (μM)^c (iron-rich)
	0.0066 ± 0.00015^d	0.39	1.56
	0.092 ± 0.007	12.5	50		2.9 ± 0.4	> 200	> 200
	0.77 ± 0.12	>200	> 200		0.175 ± 0.019	12.5	50
	0.038 ± 0.008	12.5	50	26
	18.1 ± 1.7	>200	> 200
	7.32 ± 0.9	>200	> 200		> 100	> 200	> 200
	0.061 ± 0.003	50	> 200
	0.012 ± 0.0006	12.5	50		49.8 ± 2.0	> 200	> 200
	0.020 ± 0.0014	12.5	50		17.3 ± 2.8	> 200	> 200
	0.012 ± 0.0016	0.098	0.39	29
	0.021 ± 0.001	6.25–12.5	50		> 100	> 200	> 200
	0.014 ± 0.0007	1.56	25
	4.38 ± 0.44	>200	> 200	30
	0.040 ± 0.004	1.56	25
	0.0073 ± 0.0006	0.78	3.13		2.5 ± 0.4	> 200	> 200
21	0.137 ± 0.012	>200	> 200	31	> 100	> 200	> 200
22	> 100	>200	> 200	32	> 100	> 200	> 200
23	3.7 ± 0.5	>200	> 200	33	36.5 ± 2.2	> 200	> 200

^a

Value ± std. error;

^b

grown in GAST media without added Fe³⁺;

^c

grown in GAST media supplemented with Fe³⁺;

^d

see ref. 15.