Table 1.

trans-Endocytosis of Delta into Notch⁺ cells

Delta variant expressed	Delta domain detecteda	% trans-Endocytosisb (SE)c
DeltaWT	EC domaind	27 (5)%
DeltaWT	IC domaine	22 (2)%
DeltaNGICf	EC domain	25 (2)%
DeltaNGIC	IC domain	15 (4)%
DeltaDdeg	EC domain	22 (2)%

^a The domain in the Delta variant detected in Notch⁺ cells. 

^b The frequency of trans-endocytosis was recorded as the percentage of Notch⁺ cells, in contact with Delta⁺ cells, that contain Delta-positive internalized vesicles. 

^c SE for data are average for three independent experiments. 

^d EC, extracellular. 

^e IC, intracellular. 

^f DeltaNGIC is a Delta variant in which the Delta intracellular domain is replaced with a segment of the neuroglian intracellular domain. 

^g The DeltaDde variant lacks the Delta intracellular domain.