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. 1987 May;61(5):1615–1620. doi: 10.1128/jvi.61.5.1615-1620.1987

Replicative cis-advantage of polyomavirus regulatory region mutants in different murine cell lines.

V De Simone, P Amati
PMCID: PMC254143  PMID: 3033287

Abstract

To determine the relative growth advantages of polyomavirus regulatory region mutants selected from Friend leukemic and neuroblastoma cells persistently infected with polyomavirus A2 wild type, different murine cell lines, some of which are capable of further differentiation in vitro, were used as hosts in mixed infection and transfection. The tests allowed the determination, through the measurement of cis-advantage in replication, of the most effective polyomavirus regulatory region constitutions for a given cell line and, in some cases, for specific stages of cell differentiation. Furthermore, different domains of the viral regulatory region were shown to have different effects--positive, neutral, or negative--depending on the host analyzed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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