Figure 4.

LIN-10 amino acid sequence, shown aligned with the C terminus of mammalian X11/mint proteins. Identical amino acids are boxed in black, and similar amino acids are boxed in gray. No significant sequence similarity was detected in pair-wise alignment of N-terminal LIN-10 (amino acids 1–572) with each of the X11/mint proteins. PTB, PDZ 1, and PDZ 2 domains are indicated. Positions and molecular lesions associated with lin-10 mutant alleles are indicated: *, Stop codons; ∨, RNA splice acceptor mutations; arrows, codons deleted by chromosomal deletions. These sequence data are available from GenBank.