Figure 8.

A model for MCM protein interaction. MCM4 (Cdc21p) and MCM6 (Mis5p) associate tightly as part of a core complex (thick arrows). MCM2 (Cdc19p) binds to this core complex through its interactions with Cdc21p (thin arrows). MCM5 (Nda4p) binds loosely (dashed arrows), although our experiments do not address whether this interaction occurs through MCM4 (Cdc21p), MCM2 (Cdc19p), or others. MCM3 and MCM7, not yet cloned in fission yeast, are indicated by dashed circles; their places in the model are inferred based on the work of others (Burkhart et al., 1995; Musahl et al., 1995; Kimura et al., 1996; Lei et al., 1996; Ishimi, 1997; Thömmes et al., 1997).