Table 3.

The correlation between the frequency of frame-shift start and stop codons and (a) their expected frequencies; and (b) the genomic GC content. All correlations are significant at the p < 0.001 level (sample size is 167).

Frame-Shift Codon		Phase	Combining Codons	aCorrelation Observed-Expected	bCorrelation Observed-GC%
Start	ATG	1	NAT,GNN	0.96	-0.84
		2	NNA,TGN	0.89	-0.76
	GTG	1	NGT,GNN	0.94	-0.34
		2	NNG,TGN	0.86	0.80
	TTG	1	NTT,GNN	0.96	-0.80
		2	NNT,TGN	0.87	-0.70
Stop	TAA	1	NTA,ANN	0.98	-0.87
		2	NNT,AAN	0.97	-0.93
	TAG	1	NTA,GNN	0.96	-0.89
		2	NNT,AGN	0.90	-0.84
	TGA	1	NTG,ANN	0.86	0.51
		2	NNT,GAN	0.92	-0.84