Table 1.
MisPred analysis of Swiss-Prot entries
| UniProtKB/Swiss-Prot | |||||||||||
| Conflict 1 | Number of proteins | Identified as containing an extracellular domain | Percentage | Identified as suspicious by MisPred | Percentage* | False positives | Percentage* | True errors | Percentage* | Annotated as fragment or chimera by UniProt | Identified as abnormal only by MisPred |
| Homo sapiens | 15638 | 1431 | 9.2% | 15 | 1.05% | 10 | 0.70% | 5 | 0.35% | 4 | 1 |
| Mus musculus | 13186 | 1198 | 9.1% | 12 | 1.00% | 7 | 0.58% | 5 | 0.42% | 2 | 3 |
| Rattus norvegicus | 6043 | 599 | 9.9% | 18 | 3.01% | 2 | 0.33% | 16 | 2.67% | 14 | 2 |
| Gallus gallus | 1635 | 194 | 11.9% | 22 | 11.34% | 3 | 1.55% | 19 | 9.79% | 12 | 7 |
| Danio rerio | 1290 | 64 | 5.0% | 4 | 6.25% | 3 | 4.69% | 1 | 1.56% | 1 | 0 |
| Caenorhabditis elegans | 2999 | 119 | 4.0% | 9 | 7.56% | 1 | 0.84% | 8 | 6.72% | 0 | 8 |
| Drosophila melanogaster | 2463 | 147 | 6.0% | 5 | 3.40% | 3 | 2.04% | 2 | 1.36% | 1 | 1 |
| Conflict 2 | Number of proteins | Identified as containing an extra- and an intracellular domain | Percentage | Identified as suspicious by MisPred | Percentage* | False positives | Percentage* | True errors | Percentage* | Annotated as fragment or chimera by UniProt | Identified as abnormal only by MisPred |
| Homo sapiens | 15638 | 43 | 0.3% | 8 | 18.6% | 8 | 18.6% | 0 | 0.0% | 0 | 0 |
| Mus musculus | 13186 | 42 | 0.3% | 6 | 14.3% | 6 | 14.3% | 0 | 0.0% | 0 | 0 |
| Rattus norvegicus | 6043 | 19 | 0.3% | 2 | 10.5% | 2 | 10.5% | 0 | 0.0% | 0 | 0 |
| Gallus gallus | 1635 | 10 | 0.6% | 1 | 10.0% | 1 | 10.0% | 0 | 0.0% | 0 | 0 |
| Danio rerio | 2999 | 2 | 0.1% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0 |
| Caenorhabditis elegans | 1290 | 5 | 0.4% | 1 | 20.0% | 1 | 20.0% | 0 | 0.0% | 0 | 0 |
| Drosophila melanogaster | 2463 | 8 | 0.3% | 1 | 12.5% | 1 | 12.5% | 0 | 0.0% | 0 | 0 |
| Conflict 3 | Number of proteins | Identified as suspicious by MisPred | Percentage* | False positives | Percentage* | True errors | Percentage* | Annotated as fragment or chimera by UniProt | Identified as abnormal only by MisPred | ||
| Homo sapiens | 15638 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0 | ||
| Mus musculus | 13186 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0 | ||
| Rattus norvegicus | 6043 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0 | ||
| Gallus gallus | 1635 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0 | ||
| Danio rerio | 2999 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0 | ||
| Caenorhabditis elegans | 1290 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0 | ||
| Drosophila melanogaster | 2463 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0 | ||
| Conflict 4 | Number of proteins | Proteins containing domains suitable for the study of domain integrity | Percentage | Identified as suspicious by MisPred | Percentage* | False positives | Percentage* | True errors | Percentage* | Annotated as fragment or chimera by UniProt | Identified as abnormal only by MisPred |
| Homo sapiens | 15638 | 6973 | 44.6% | 10 | 0.14% | 6 | 0.09% | 4 | 0.06% | 3 | 1 |
| Mus musculus | 13186 | 5808 | 44.0% | 3 | 0.05% | 2 | 0.03% | 1 | 0.02% | 1 | 0 |
| Rattus norvegicus | 6043 | 2756 | 45.6% | 14 | 0.51% | 0 | 0.00% | 14 | 0.51% | 13 | 1 |
| Gallus gallus | 1635 | 755 | 46.2% | 8 | 1.06% | 0 | 0.00% | 8 | 1.06% | 8 | 0 |
| Danio rerio | 1290 | 355 | 27.5% | 1 | 0.28% | 0 | 0.00% | 1 | 0.28% | 1 | 0 |
| Caenorhabditis elegans | 2999 | 1215 | 40.5% | 2 | 0.16% | 0 | 0.00% | 2 | 0.16% | 0 | 2 |
| Drosophila melanogaster | 2463 | 1203 | 48.8% | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% | 0 | 0 |
| Conflict 5 | Number of proteins | Identified as suspicious by MisPred | Percentage* | False positives | Percentage* | True errors | Percentage* | Annotated as fragment or chimera by UniProt | Identified as abnormal only by MisPred | ||
| Homo sapiens | 15638 | 5 | 0.03% | 3 | 0.02% | 2 | 0.01% | 0 | 2 | ||
| Mus musculus | 13186 | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% | 0 | 0 | ||
| Rattus norvegicus | 6043 | 5 | 0.08% | 3 | 0.05% | 2 | 0.03% | 0 | 2 | ||
| Gallus gallus | 1635 | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% | 0 | 0 | ||
| Danio rerio | 1290 | 18 | 1.40% | 18 | 1.40% | 0 | 0.00% | 0 | 0 | ||
| Caenorhabditis elegans | 2999 | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% | 0 | 0 | ||
| Drosophila melanogaster | 2463 | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% | 0 | 0 | ||
*Values for suspicious, false positive and true positive sequences are expressed as percentage of the proteins relevant for the given conflict.