Table 4. Power calculations.
| Genotypic relative risk Aa/AA | Linkage Disequilibrium D’ | Risk and marker allele frequency | Power at α=0.05 |
|---|---|---|---|
| 1.5/2.0 |
0.8 |
0.2 |
0.4 |
| 0.3 |
0.44 |
||
| 0.4 |
0.44 |
||
| 1.5/2.0 |
1 |
0.2 |
0.57 |
| 0.3 |
0.62 |
||
| 0.4 |
0.61 |
||
| 2.0/3.0 |
0.8 |
0.2 |
0.83 |
| 0.3 |
0.84 |
||
| 0.4 |
0.8 |
||
| 2.0/3.0 |
1 |
0.2 |
0.96 |
| 0.3 |
0.96 |
||
| 0.4 | 0.94 |
Power in this population-based study to detect a significant genetic association for pseudoexfoliation syndrome at the α=0.05 level for different degrees of linkage disequilibrium and allele frequency. Aa=heterozygote, AA=high risk homozygote.