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. 2008 Oct 3;4(10):e1000171. doi: 10.1371/journal.ppat.1000171

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A). PBMCs from cynomolgus macaques and humans were co-incubated with 20 µg/ml YU2 trimers or (B) with 5 µg/ml YU2gp120 (only human PBMCs). CD4 specific trimer binding (blue) to CD3⁺/CD4⁺/CD8⁻ cells was detected with either the V3-directed mAb, 447-52D (left panels), or with the co-receptor site-directed mAb, 17b (right panels), by flow cytometry analysis. Negative control staining (red, both panels) shows the fluorescence signal obtained in the absence of 447-52D or 17b.