TABLE 1.
CLINICAL CHARACTERISTICS OF STUDY POPULATION AT THE TIME OF VENTILATOR-ASSOCIATED PNEUMONIA ONSET
| Type III Secretory Phenotype (+) (n = 25) | Type III Secretory Phenotype (−) (n = 9) | P Value | |
|---|---|---|---|
| Age, yr, mean ± SD | 64.2 ± 12.8 | 63.7 ± 11.5 | 0.90 |
| Sex, no. male/female | 18/7 | 5/4 | 0.42 |
| Charlson index, median (range) | 3 (1–6) | 3 (1–6) | 0.48 |
| Prior antibiotics | 14 (56%) | 3 (33%) | 0.44 |
| PaO2/FiO2, mean ± SD | 229.1 ± 98.6 | 234.1 ± 73.0 | 0.88 |
| Bilateral infiltrate | 16 (64%) | 4 (45%) | 0.43 |
| Days of MV before VAP, mean ± SD | 15.6 ± 4.7 | 12.2 ± 2.7 | 0.02 |
| Bacteremia | 3 (12%) | 0 | 0.55 |
| APACHE II score, mean ± SD | 25.7 ± 5.6 | 21.6 ± 4.9 | 0.07 |
| MODS, median (range) | 3 (2–8) | 3 (1–5) | 0.21 |
| Time to first dose of antibiotics from VAP onset, h, mean ± SD | 6.7 ± 3.2 | 6.3 ± 3.0 | 0.77 |
Definition of abbreviations: APACHE II = Acute Physiology and Chronic Health Evaluation II; MODS = Multiple Organ Dysfunction Score; MV = mechanical ventilation; VAP = ventilator-associated pneumonia.