TABLE 1.
HLA alleles associated with HBV clearance and persistence and their known haplotypes
| Allele or haplotype | Frequency (%) in subjects with:
|
OR | 95% CI | P | |
|---|---|---|---|---|---|
| Clearance (n = 342) | Persistence (n = 194) | ||||
| Alleles associated with clearance | |||||
| A*0301 | 15.7 | 8.1 | 0.47 | 0.30-0.72 | 0.0005 |
| DRB1*1302 | 4.9 | 2.1 | 0.42 | 0.19-0.93 | 0.03 |
| Alleles associated with persistence | |||||
| B*08 | 8.1 | 12.2 | 1.59 | 1.04-2.43 | 0.03 |
| B*44 | 11.9 | 19.4 | 1.82 | 1.27-2.60 | 0.001 |
| Cw*0501 | 6.8 | 12.1 | 1.81 | 1.16-2.82 | 0.009 |
| Cw*1601 | 2.4 | 5.3 | 2.14 | 1.09-4.18 | 0.03 |
| DQB1*0201 | 20.1 | 27.8 | 1.56 | 1.15-2.09 | 0.004 |
| DRB1*0301 | 9.6 | 15.1 | 1.66 | 1.13-2.42 | 0.009 |
| Haplotype from alleles associated with clearance | |||||
| A*0301-B*07 | 6.1 | 4.0 | 0.64 | 0.34-1.19 | 0.16 |
| Haplotypes from alleles associated with persistence | |||||
| A*0101-B*08- | 5.3 | 8.0 | 1.58 | 0.93-2.68 | 0.09 |
| DQA1*0501- | |||||
| DQB1*0201- | |||||
| DRB1*0301 | |||||
| B*44-Cw*1601 | 2.4 | 5.4 | 2.23 | 1.13-4.42 | 0.02 |
| B*44-Cw*0501 | 5.3 | 10.4 | 1.99 | 1.22-3.24 | 0.006 |
| B*44-DRB1*0701 | 4.6 | 7.8 | 1.83 | 1.06-3.15 | 0.03 |
| B*44-Cw*1601- | 2.0 | 4.3 | 2.21 | 1.04-4.71 | 0.04 |
| DRB1*0701 | |||||