TABLE 3.
Association of HLA class I and class II heterozygosity and hepatitis B virus outcomes
| Frequency (%) of all heterozygous subjects witha:
|
OR | 95% CI | P | ||
|---|---|---|---|---|---|
| Clearance (n = 342) | Persistence (n = 194) | ||||
| Class I | |||||
| 2-digit nomenclature | 74.9 | 70.0 | 0.76 | 0.50-1.14 | 0.18 |
| 4-digit nomenclature | 79.5 | 73.8 | 0.69 | 0.45-1.07 | 0.10 |
| Class II | 77.8 | 69.7 | 0.62 | 0.40-0.95 | 0.03 |
| Univariate | |||||
| DQA1 | 81.6 | 76.2 | 0.70 | 0.44-1.01 | 0.12 |
| DQB1 | 86.9 | 78.8 | 0.50 | 0.31-0.83 | 0.008 |
| DRB1 | 91.4 | 86.9 | 0.56 | 0.32-1.00 | 0.05 |
| Multivariate | |||||
| DQA1 | NA | NA | 1.12 | 0.58-2.14 | 0.74 |
| DQB1 | NA | NA | 0.50 | 0.26-2.14 | 0.05 |
| DRB1 | NA | NA | 0.80 | 0.34-1.89 | 0.61 |
a
NA, not applicable.