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. 2008 Sep 22;182(6):1083–1097. doi: 10.1083/jcb.200803174

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© 2008 Brown et al.

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Figure 7. — Positioning of multiple up-regulated genes. (a) M-FISH detection of concurrent associations between genes HBA, SLC4A1, ERAF, and HBB scored in erythroblast and lymphoblast nuclei. Up to seven FISH signals were found together in nuclear association in intermediate erythroblasts compared with a maximum of three in lymphoblasts. (b) M-FISH detection of HBA (red), SLC4A1 (green), ERAF (blue), and HBB (white) within erythroblast nuclei (gray). Associating signals are not grouped tightly around a single point but in a curvilinear manner. Panels (left to right) show groups of five, four, and three genes. Bar, 4 μm.