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. 2008 Sep 22;182(6):1171–1184. doi: 10.1083/jcb.200802091

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© 2008 Wang et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — Summary of myosin II inhibition effects on myelination by SC and OL. Myosin II is an important regulator of SC cytoskeleton during differentiation and myelination. Myosin II appears to be necessary for the establishment of SC polarity and elongation along the axons, a crucial step in the initiation of myelin formation in the PNS. In the absence of myosin II activity, SC are unable to segregate axons in a 1:1 relationship and myelinate. In contrast, OL differentiation and myelin formation are independent of myosin II activity. Furthermore, down-regulation of myosin II promotes actin polymerization and branching, and also results in a significant increase in the amount of myelinated segments formed in culture.