Figure 7.
Decreased dystroglycan and Bcam at AChR clusters lacking laminins α4 and α5. (A and B) Control and Lama4−/−;Lama5M/M cultures were stained for AChR, dystroglycan (A) and Bcam (B). Levels of both antigens are decreased at clusters on mutant myotubes. Bars, 10 μm. (C and D) Dystroglycan relative fluorescence intensity in AChR clusters from control and Lama4−/−;Lama5M/M myotubes cultured on laminin 111 (C) or fibronectin (D). Counts show mean ± SEM from at least three independent cultures, >75 AChR clusters per culture. *, significant by unpaired t test, P < 0.002.