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IFN-γ in H-2q mice protects spinal neurons from death. (A) Normal anterior horn cell neurons in an IFN-γ+/− H-2q mouse at 21 days after TMEV infection. (B) Anterior horn cell loss in an IFN-γ−/− H-2q mouse at 13 days after TMEV infection. Arrowheads indicate remnants of anterior horn cells along with intense inflammatory infiltration. No examples of anterior horn cell death like that shown here were observed in IFN-γ+/+ H-2q or IFN-γ+/− H-2q mice following TMEV infection.
