TABLE 1.
Spinal cord pathologic changes in IFN-γ−/− mice of H-2b haplotype
| Day | Mice (no. tested) | Mean ± SEM score for:
|
||
|---|---|---|---|---|
| Inflammation
|
Demyelination | |||
| Gray matter | White matter | |||
| 7 | IFN-γ−/− (9) | 3.6 ± 1.1a | 1.3 ± 0.5 | 0.0 ± 0.0 |
| IFN-γ+/+ (7) | 19.1 ± 4.8 | 2.1 ± 0.8 | 0.0 ± 0.0 | |
| 16 | IFN-γ−/− (9) | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| IFN-γ+/+ (7) | 0.0 ± 0.0 | 1.1 ± 0.6 | 0.0 ± 0.0 | |
| 21 | IFN-γ−/− (16) | 0.0 ± 0.0 | 1.3 ± 0.6 | 2.5 ± 0.9 |
| IFN-γ+/+ (10) | 0.2 ± 0.2 | 0.0 ± 0.0 | 0.2 ± 0.2 | |
| 45 | IFN-γ−/− (8) | 1.2 ± 0.7 | 5.1 ± 2.1 | 13.9 ± 4.7 |
| IFN-γ+/+ (8) | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
a
Significantly different from values for IFN-γ+/+ mice at 7 days postinfection, as determined by Mann-Whitney rank sum test (P = 0.001).