TABLE 2.
Day | Mice (no. tested) | Mean ± SEM score for:
|
||
---|---|---|---|---|
Inflammation
|
Demyelination | |||
Gray matter | White matter | |||
7 | IFN-γ−/− (5) | 7.8 ± 3.7 | 3.1 ± 2.1 | 0.0 ± 0.0 |
IFN-γ+/− (6) | 6.4 ± 3.6 | 4.0 ± 2.0 | 0.0 ± 0.0 | |
IFN-γ+/+ (2) | 8.6 ± 8.6 | 7.2 ± 4.9 | 0.0 ± 0.0 | |
11-17 | IFN-γ−/− (16) | 24.7 ± 4.6a | 3.8 ± 1.8 | 0.0 ± 0.0 |
IFN-γ+/− (7) | 5.7 ± 1.3 | 1.6 ± 0.8 | 0.0 ± 0.0 | |
16 | IFN-γ+/+ (7) | 0.5 ± 0.3 | 2.4 ± 1.0 | 2.0 ± 0.6 |
21 | IFN-γ−/− (10) | 6.1 ± 3.4 | 5.6 ± 1.5 | 4.1 ± 1.5 |
IFN-γ+/− (7) | 5.4 ± 4.3 | 4.9 ± 3.0 | 4.1 ± 2.4 | |
IFN-γ+/+ (14) | 0.0 ± 0.0 | 3.0 ± 1.3 | 2.6 ± 1.6 |
Significantly different from values for IFN-γ+/− and IFN-γ+/+ mice, as determined by Mann-Whitney rank sum test (P = 0.016 and P = 0.005, respectively).