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CD8 T cells in Fas-deficient mice are primed to express elevated levels of FasL upon activation. Enriched splenic T cells from B6 and B6.lpr mice were activated for 4 h by plate-bound anti-CD3e antibody as described in Methods. Cells were then stained with antibodies for the indicated markers and levels of expression of surface FasL on various sub-populations evaluated by flow cytometry. FasL levels on cells gated for expression of CD3 only, CD3 and CD4 or CD3 and CD8 are shown.
