Figure 4. Cholangiocyte populations undergoing EMT during biliary fibrosis in humans are Hh responsive.
Gli2 (brown) localized in nuclei of ductular cells expressing S100A4 (A), vimentin (B), and CK-7 (C) in representative liver sections from PBC patients. Positivity for S100A4, vimentin, or CK-7 is shown as blue cytoplasmic staining. Original magnification, ×100 (A–C).