Figure 1. B cells regulate EAE severity.

B6 mice were treated with CD20 or control mAb (250 μg) before or after MOG immunization (days –7, 7, 14, or 21) and scored daily for EAE disease severity. Arrowheads indicate the day of mAb injection. Values represent (mean ± SEM) EAE clinical scores from more than 5 mice in each group, with similar results obtained in 3 independent experiments. Significant differences between CD20 and control mAb–treated groups are indicated; *P < 0.05.