Table 1.

Dicer mutant mice are defective in cardiac function

Genotypes	Heart rate, bpm	IVSd, mm	IVSs, mm	LVPWd, mm	LVPWs, mm	LVIDd, mm	LVIDs, mm	FS, %
+/+ (n = 10)	555.9 ± 42.33	0.348 ± 0.06	0.604 ± 0.12	0.355 ± 0.07	0.624 ± 0.13	1.248 ± 0.13	0.696 ± 0.15	44.63 ± 8.86
−/− (n = 7)	278.6 ± 64.38	0.40 ± 0.12	0.57 ± 0.15	0.571 ± 0.10	0.713 ± 0.10	1.517 ± 0.25	1.287 ± 0.16	19.77 ± 5.31
+/− (n = 8)	537.4 ± 48.28	0.335 ± 0.05	0.573 ± 0.09	0.295 ± 0.04	0.567 ± 0.17	1.306 ± 0.16	0.756 ± 0.16	42.34 ± 8.52
P value	<0.0001	0.296	0.629	0.0001	0.170	0.01	<0.0001	<0.0001

Echocardiographic analyses of P0 wild-type (+/+), Dicer heterozygous (+/-), and homozygous (-/-) mutant mice. Values were quantified from five independent M-mode measurements. IVSd, interventricular septal thickness at end diastole; IVSs, interventricular septal thickness at end systole; LVPWd, left ventricular posterior wall thickness at end diastole; LVPWs, left ventricular posterior wall thickness at end systole; LVIDd, left ventricular internal diameter at end diastole; LVIDs, left ventricular internal diameter at end systole; and FS, fractional shortening.