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. Author manuscript; available in PMC: 2008 Sep 18.
Published in final edited form as: Chem Res Toxicol. 2006 Dec;19(12):1580–1594. doi: 10.1021/tx060164e

Figure 6.

Figure 6

Events downstream of methyl base damage can lead to homologous recombination repair. BER intermediates or unrepaired methyl damage encountered by replication, or MMR recognition of O6-MeG:T mispairs can induce homologous recombination events. Homologous recombination promotes strand invasion onto a sister chromatid template to initiate repair. DNA synthesis and resolution of the Holliday junction completes the process. If left unrepaired, double strand breaks lead to chromosomal rearrangements.