TABLE 2.
MICs and Tlag endpointsa of each drug for each species
| Species (no. of strains) | Drug | Median MIC-0 (mg/liters) (range) | Median MIC-2 (mg/liters) (range) | Tlag10 | Tlag50 | Tlag75 | Tlaggcc | Tlag10 − Tlaggc | Tlag50 − Tlaggc | Tlag75 − Tlaggc |
|---|---|---|---|---|---|---|---|---|---|---|
| R. oryzae (6) | TB | 0.5 (0.25-1) | 0.5 (0.25-1) | 11.1 ± 3.8 | 7.7 ± 2.0 | 7.7 ± 2.2 | 6.7 ± 3.4 | 3.4 ± 2.3 | 3.4 ± 2.3 | |
| IT | 32 (2->32) | 3 (1->32) | ND | 5.3 ± 0.8 | 5.0 ± 1.0 | 4.4 ± 0.9 | ND | 0.9 ± 0.4 | 0.6 ± 0.3 | |
| AB | 1 (0.5-1) | NDb | 17.4 ± 1.6 | 15.1 ± 1.6 | 12.0 ± 2.0 | 13.0 ± 1.3 | 10.7 ± 1.8 | 7.5 ± 2.6 | ||
| A. fumigatus (6) | TB | 16 (8->32) | 3 (1-16) | 21.9 ± 2.6 | 11.0 ± 1.8 | 8.8 ± 0.8 | 13.9 ± 3.4 | 3.1 ± 2.4 | 0.9 ± 1.1 | |
| IT | 1 (0.5->32) | 0.5 (0.25->32) | 13.5 ± 3.6 | 11.4 ± 1.8 | 9.4 ± 0.6 | 7.9 ± 1.1 | 5.6 ± 3.5 | 3.5 ± 1.2 | 1.5 ± 1.0 | |
| AB | 1 (0.5-4) | ND | 21.8 ± 4.1 | 14.9 ± 3.2 | 10.5 ± 1.9 | 13.9 ± 4.6 | 7.0 ± 2.9 | 2.5 ± 2.2 | ||
| A. flavus (6) | TB | 0.125 (0.125-0.5) | 0.06 (0.03-0.125) | 14.3 ± 3.0 | 8.4 ± 1.2 | 6.6 ± 0.7 | 7.9 ± 3.2 | 2.0 ± 0.9 | 0.2 ± 0.4 | |
| IT | 0.5 (0.5) | 0.5 (0.25-0.5) | 8.6 ± 1.1 | 8.2 ± 0.4 | 6.7 ± 0.5 | 6.5 ± 0.8 | 2.1 ± 0.7 | 1.8 ± 0.7 | 0.3 ± 0.4 | |
| AB | 2 (1-4) | ND | 21.0 ± 3.0 | 15.9 ± 4.6 | 8.5 ± 1.0 | 14.5 ± 3.2 | 9.4 ± 4.1 | 2.0 ± 0.8 | ||
| S. prolificans (6) | TB | >32 | 32 (32->32) | ND | ND | 15.6 ± 1.5 | ND | ND | 4.0 ± 1.8 | |
| IT | >32 | >32 | ND | ND | 13 ± 1.7 | 11.6 ± 1.5 | ND | ND | 1.4 ± 1.0 | |
| AB | >16 (4->16) | ND | 19.1 ± 2.9 | 15.2 ± 2.4 | ND | 7.5 ± 3.2 | 3.6 ± 2.5 |
a
Tlag10, Tlag50, and Tlag75 are the mean Tlag values of the growth curves at the highest drug concentration showing more than 10, 50, and 75% growth, respectively, compared to the growth control after 24 h (R. oryzae), 48 h (Aspergillus spp.), and 72 h (S. polificans) of incubation. Tlag values are shown ±95% CIs.
b
ND, not determined.
c
Values correspond with fungal species, regardless of drug used.