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Dissociation constants of REP-1 in binary complexes with Rab7 variants and of RabbGGTase in ternary complexes with REP-1–Rab7 variants
| Complex | Kd (REP-1) (nM) | Kd (RabGGTase) (nM) |
|---|---|---|
| Rab7C(NBD)SC | 2.8±0.8 | 61±6.9 |
| Rab7C(NBD)SCC | 3.2±0.9 | ND |
| Rab7WT | 7.5±2.7 | 130±9.3 |
| Rab7I 190H | 228±59 | ND |
| Rab7 L192S | 341±74 | ND |
| Rab7I 190HL192S | 547±46 | ND |
| Rab7Δ3 | 16.1±1.0 | 191±22 |
| Rab7Δ14 | 15.8±2.1 | 321±11 |
| Rab7Δ22 | 381±37 | 491±31 |
| Rab7-5A | 21.5±1.1 | 188±45 |
| Rab7_WFY | ND | 107±16 |
| ND, not determined. | ||
