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. 2008 Oct;173(4):962–972. doi: 10.2353/ajpath.2008.080358

Figure 7.

Figure 7

Deletion of JNK1 or JNK2 does not affect ConA-induced non-apoptotic liver injury. A: Serum ALT levels from WT, JNK1−/− or JNK2−/− mice treated with ConA for 6 or 8 hours were measured (mean ± SD). There are no statistical differences between the WT and the JNK1 or the JNK2-deficient mice. B: Sections of livers from WT (a–b), JNK1−/− (c–d), or JNK2−/− (e–f) mice treated with ConA (b, d, f) for 8 hours or untreated (a, c, e) were H&E stained. C: WT, JNK1−/−, or JNK2−/− mice were treated with ConA and sacrificed at 6 or 8 hours later. Liver cytosols were subjected to the immunoblot assay with the indicated antibodies. Asterisks indicated non-specific bands. Lane 10 represents a sample of WT mouse treated with ConA/GalN for 8 hours. D: The same lysates as those used in (B) were examined for caspase activities using the corresponding substrates. Results (mean ± SD) are expressed as fold of changes over the non-treated control.