Table 1.
Biochemical Findings and Liver and Body Weights
| 6-Month control | 6-Month Western diet | 7-Month Western diet followed by 2.5 months of
|
|||
|---|---|---|---|---|---|
| Western diet | Western diet + D-4F | Western diet + SR141716 | |||
| Body weight (g) | 28.1 ± 1.1 | 45.9 ± 1.2 | 40 ± 5.2 | 39.5 ± 0.8 | 29.1 ± 2.0 |
| Liver weight (g) | 1.34 ± 0.05 | 3.7 ± 0.2 | 2.74 ± 0.67 | 2.42 ± 0.04 | 1.54 ± 0.1 |
| AST (U/L) | 54.7 ± 10.0 | 250.7 ± 27.1 | 268 ± 29.6 | 211.9 ± 19.1 | 109.6 ± 10.4 |
| ALT (U/L) | 18.8 ± 4.0 | 300.0 ± 37.1 | 235.2 ± 23.5 | 277.3 ± 18.2 | 54.8 ± 12.4 |
| Cholesterol (mg/dl) | 90.0 ± 5.1 | 274.1 ± 22.1 | 288.0 ± 5.4 | 146.8 ± 2.1 | 112.2 ± 13.7 |
| Triglycerides (mg/dl) | 50.7 ± 7.7 | 32.4 ± 5.6 | 38.0 ± 4.4 | 40.0 ± 6.7 | 33.1 ± 2.2 |
| Glucose (mg/dl) | 65.0 ± 1.2 | 261.0 ± 24.2 | 270.2 ± 10.0 | 231.2 ± 18.0 | 136.3 ± 29.2 |
| Insulin (ng/ml) | 0.47 ± 0.06 | 2.21 ± 0.09 | 3.27 ± 3.0 | 3.7 ± 1.1 | 0.81 ± 0.15 |
| HOMA-IR | 2.2 ± 0.3 | 40.9 ± 4.2 | 62.8 ± 5.1 | 63.3 ± 23.5 | 8.8 ± 3.6 |
| TBARS (nmol/g tissue) | 18.7 ± 1.2 | 16.4 ± 0.4 | 27.1 ± 4.0 | 29.4 ± 2.4 | 17.1 ± 0.7 |
| GSH (nmol/mg protein) | 91.8 ± 3.8 | 71.2 ± 3.9 | 39.6 ± 4.8 | 50.1 ± 5.8 | 68.7 ± 2.0 |
| Leptin (ng/ml) | 1.89 ± 0.29 | 24.0 ± 2.2 | 32.62 ± 1.86 | 17.49 ± 1.41 | 2.36 ± 1.05 |
| Adiponectin (μg/ml) | 22.9 ± 0.3 | 31.1 ± 1.9 | 17.3 ± 0.8 | 15.3 ± 1.0 | 18.4 ± 1.8 |
| 6-Month control | 6-Month Western diet | 7-Months Western diet followed by 2.5 months of
|
|||
| Chow
|
Chow + D-4F
|
Chow + SR141716
|
|||
| Body weight (g) | 28.1 ± 1.1 | 45.9 ± 1.2 | 34.6 ± 1.2 | 35.9 ± 3.2 | 30.2 ± 1.1 |
| Liver weight (g) | 1.34 ± 0.05 | 3.7 ± 0.2 | 1.54 ± 0.09 | 1.67 ± 0.19 | 1.39 ± 0.1 |
| AST (U/L) | 54.7 ± 10.0 | 250.7 ± 27.1 | 107.2 ± 20.5 | 104.2 ± 22.4 | 69.1 ± 5.5 |
| ALT (U/L) | 18.8 ± 4.0 | 300.0 ± 37.1 | 44.0 ± 4.0 | 69.1 ± 21.5 | 59.1 ± 11.4 |
| Cholesterol (mg/dl) | 90.0 ± 5.1 | 274.1 ± 22.1 | 108.6 ± 4.7 | 120.8 ± 2.9 | 105.3 ± 4.7 |
| Triglycerides (mg/dl) | 50.7 ± 7.7 | 32.4 ± 5.6 | 36.2 ± 6.6 | 49.1 ± 1.4 | 47.0 ± 2.2 |
| Glucose (mg/dl) | 65.0 ± 1.2 | 261.0 ± 24.2 | 137.2 ± 18.6 | 159.2 ± 2.4 | 96.2 ± 3.0 |
| Insulin (ng/ml) | 0.47 ± 0.06 | 2.21 ± 0.09 | 1.78 ± 0.39 | 1.46 ± 0.2 | 0.89 ± 0.27 |
| HOMA-IR | 2.2 ± 0.3 | 40.9 ± 4.2 | 18.1 ± 5.1 | 16.5 ± 2.2 | 6.1 ± 2.0 |
| TBARS (nmol/g tissue) | 18.7 ± 1.2 | 16.4 ± 0.4 | 20.4 ± 0.3 | 20.0 ± 0.6 | 18.7 ± 1.09 |
| GSH (nmol/mg protein) | 91.8 ± 3.8 | 71.2 ± 3.9 | 85.1 ± 3.8 | 82.8 ± 5.2 | 73.8 ± 2.2 |
| Leptin (ng/ml) | 1.89 ± 0.29 | 24.0 ± 2.2 | 9.36 ± 0.76 | 8.70 ± 1.43 | 1.95 ± 0.72 |
| Adiponectin (μg/ml) | 22.9 ± 0.3 | 31.1 ± 1.9 | 19.3 ± 1.1 | 18.52 ± 1.5 | 16.5 ± 2.0 |