Figure 8.

Expression levels of several identified citrullinated proteins in brains of control and scrapie-infected mice. Proteins that had been identified as citrullinated were analyzed by Western blot in homogenates from whole brain, cerebral cortex, hippocampus, striatum, cerebellum, and brain stem. The proteins included ALDC, NSE, GFAP, MBP, and actin as a control stain. Note that ALDC and GFAP were significantly increased in scrapie-infected mice. In contrast, NSE was slightly decreased in whole brain, hippocampus, and cerebellum and MBP was significantly decreased in cerebral cortex, brain stem, hippocampus, and striatum in brains from scrapie-infected mice compared to controls.