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. 2008 Oct;173(4):1143–1152. doi: 10.2353/ajpath.2008.080478

Figure 5.

Figure 5

Fingolimod reciprocally modulates S1P1 and S1P5 receptor transcripts in human adult mature OLGs in a cyclic manner. qPCR results for S1P5 (A) and S1P1 (B) were normalized to β-actin in the respective sample and normalized to untreated cultures at the respective time point. At 4 hours of treatment with fingolimod-phosphate (1 μmol/L), S1P5 is down-regulated and S1P1 is concomitantly up-regulated relative to control. By 2 days of treatment, S1P1 is down-regulated and S1P5 is up-regulated. The opposite is observed at 8 days of treatment. At all time points, S1P3 levels remained low and S1P4 remained undetectable. S1P receptor levels were progressively decreased throughout time in untreated cultures likely because of the presence of S1P in the serum-supplemented media. *P < 0.05 relative to control; δP < 0.05, δδP < 0.01, δδδP < 0.001 relative to previous time point.