Figure 2.

Immunoreactivity of NANOG in first trimester placenta (A), term placenta (B), HM that regressed (C), HM that subsequently developed persistent trophoblastic neoplasia (D), and choriocarcinoma (E). NANOG immunoreactivity was mainly detected in the nuclei of cytotrophoblast (CT) and was absent in syncytiotrophoblast (ST) (see arrows). Insets highlighting selected regions of the trophoblasts at higher magnification are included. F: Bar chart of nuclear immunoreactivity of NANOG in first trimester placentas (First), term placentas (Term), HM that regressed (HM-R), HM that subsequently developed persistent trophoblastic neoplasia (HM-GTN), and choriocarcinomas (CCA). Nuclear immunoreactivity of NANOG was analyzed by Mann-Whitney test.