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. 2008 Oct;173(4):1173–1185. doi: 10.2353/ajpath.2008.071131

Figure 1.

Figure 1

The graph (A) and bar graph (B) showing tumor growth delay and central necrosis. A, B: PTK/ZK and radiation delayed tumor growth (A) and induced central necrosis (estimated as a ratio “volume tumor necrosis/entire tumor volume”) (B). Mean values (n ≥3) are represented together with the SD. *Value is significantly different from the control (*P ≤ 0.02). Tumor growth was inhibited by both treatment strategies. C, C′: Vascular casts of MMTV/c-neu mammary carcinoma xenografts, on day 5 (C) and day 9 (C′) after onset of treatment with PTK/ZK. Large avascular areas (asterisks) are apparent within the medullary region. Multiple tiny capillary sprouts emanate from the preserved cortical vessels and invade the avascular medulla (arrowheads). D–F: Transmission electron micrographs illustrating changes in the vessels. In (D), a vessel in a non-treated tumor with intact endothelium is shown. E, F: Attenuation with partial denudation (see inserts) and vacuolization (asterisks) of endothelial cells in the tumor vessels after treatment with PTK/ZK (E) or irradiation (F). The magnification is ×3600; the scale bar is presented in (D).