TABLE 1.
Comparison of antibiotic susceptibility determined by Bronx box and luminometry with PM as reference
| Antibiotic or resistance level patterna | Method | Agreementb | Sensitivityc | Specificityd |
|---|---|---|---|---|
| Antibiotics | ||||
| INH (0.2) | Luminometry | 97.9 (47/48) | 100 (23/23); 82.2-100 | 96.0 (24/25); 77.7-99.8 |
| Bronx box | 100 (44/44) | 100 (19/19); 79.1-100 | 100 (25/25); 83.4-100 | |
| INH (1.0) | Luminometry | 97.9 (47/48) | 100 (23/23); 82.2-100 | 96.0 (24/25); 77.7-99.8 |
| Bronx box | 90.9 (40/44) | 78.9 (15/19); 53.9-93.0 | 100 (25/25); 83.4-100 | |
| RIF (1.0) | Luminometry | 91.7 (44/48) | 100 (11/11); 67.9-100 | 89.2 (33/37); 73.6-96.5 |
| Bronx box | 95.5 (42/44) | 100 (10/10); 65.5-100 | 94.1 (32/34); 78.9-99.0 | |
| STR (2.0) | Luminometry | 87.5 (42/48) | 78.9 (15/19); 53.9-93.0 | 93.1 (27/29); 75.8-98.8 |
| Bronx box | 72.7 (32/44) | 80.0 (12/15); 51.4-94.7 | 69.0 (20/29); 49.0-84.0 | |
| EMB (5.0) | Luminometry | 89.6 (43/48) | 40.0 (2/5); 7.3-83.0 | 95.3 (41/43); 82.9-99.2 |
| Bronx box | 95.5 (42/44) | 33.3 (1/3); 1.8-87.5 | 100 (41/41); 89.3-100 | |
| Resistance patterns | ||||
| MDR (INH and RIF) | Luminometry | 89.6 (43/48) | 100 (10/10); 65.5-100 | 86.8 (33/38); 71.1-95.1 |
| Bronx box | 95.5 (42/44) | 100 (9/9); 62.9-100 | 94.3 (33/35); 75.9-99.0 | |
| Any resistance (INH, RIF, EMB, or STR) | Luminometry | 92.9 (223/240) | 91.4 (74/81); 82.5-96.2 | 93.7 (149/159); 88.4-96.8 |
| Bronx box | 90.9 (200/220) | 86.4 (57/66); 75.2-93.2 | 92.9 (143/154); 87.3-96.2 |
For antibiotics, values in parentheses are drug concentrations (in micrograms per milliliter). For each resistance patterns, the antibiotics to which resistance was demonstrated are listed in parentheses.
Values are percentages. The values in parentheses are numbers of concordant results/total numbers of results.
The value listed is a percentage indicating the ability of LRPs to detect resistance. For each entry, the value in parentheses is the number of isolates resistant by both methods/number of isolates resistant by PM and the 95% CI is given following the semicolon.
The value listed is a percentage indicating the ability of LRPs to detect susceptibility. For each entry, the value in parentheses is the number of isolates susceptible by both methods/number of isolates susceptible by PM and the 95% CI is given following the semicolon.