Figure 7.

The effect of osteoblastic expression of a dominant-negative type II TGF-β receptor on the mineral apposition rate in the femoral epiphyses of wild-type and D4 mice at day 35. Transgenic E1 mice were crossed to D4 mice to generate doubly transgenic D4/E1 mice. Values represent the mean ± SD of wild-type (n = 5), D4 (n = 4), E1 (n = 5), and D4/E1 (n = 4) mice. Mineral apposition rates in D4 and D4/E1 mice were significantly elevated compared with wild-type (∗, p < 0.0001), yet were not significantly different from one another. The mineral apposition rate in E1 mice was not significantly different from wild-type.