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Two models for generating sod2 extrachromosomal, linear amplicons. DNA replication is presumed to have occurred before either event; the second copy of chromosome I has been omitted for clarity. S, sod2; large filled circles, centromeres; triangles, telomere from the long arm of chromosome I; small filled circles, telomere from the short arm of chromosome I; filled square, de novo telomere; arrows, inverted DNA repeats.
