TABLE 4.
Antibiotic | Disk diffusion results
|
MIC (μg/ml) as determined by:
|
Synergy with PENa
|
||||||
---|---|---|---|---|---|---|---|---|---|
Disk content (μg) | Zone diam (mm)
|
Etest
|
Agar dilution
|
||||||
SR362 | Otherb | SR362 | Otherb | SR362 | Otherb | SR362 | Otherb | ||
GEN | 120 | 10 | 15-20 | 128 | 32 | 128 | 32 | No | Yes |
KAN | 120 | 6 | 6-15 | >256 | >256 | >2,048 | 256-512 | No | Yes |
1,000 | 6 | 17-20 | |||||||
AMK | NTc | NT | NT | >256 | 128->256 | >2,048 | 256 | No | Yes |
STR | 300 | 15 | 14-22 | 256 | 256 | 256 | 256 | Yes | Yes |
Synergy was considered when the bacterial concentration diminished >2 logs for the combination respective to PEN after 6 h of incubation at 35°C.
That is, the other 57 isolates obtained during the study.
NT, not tested.