FIG. 1.

Kinetics of circulating mannan (•) and antimannan antibodies (○) in sequentially drawn sera from seven adult neutropenic patients (panels 1 to 7, respectively) with systemic candidiasis. The evolution of mannanemia and antimannan antibodies (the levels of which are given in AU) is shown, together with leukocyte (WBC) counts (the bottom part of each figure) and the number of negative blood cultures (vertical bars preceding day 0), as a function of time in relation to day 0, which represents the day on which the first blood sample positive for C. tropicalis by culture was taken. The horizontal dotted line represents the cutoff values of the tests (0.5 ng/ml for the mannanemia test and 10 AU for the antimannan antibody test).