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. Author manuscript; available in PMC: 2008 Oct 18.
Published in final edited form as: J Med Chem. 2007 Sep 26;50(21):5217–5226. doi: 10.1021/jm070705c

Scheme 2.

Scheme 2

Syntheses of 1-adamantyl-3-substituted alkyl-ureas: (a) Ph3P, CBr4, DMF, rt, (b) 2-hexanol (for compound 11), 2-methyl-1-pentanol (for compound 12), or triethylene glycol monomethyl ether (for compound 18), NaH, DMF, rt, (c) Ph3P, CBr4, THF, rt, (d) compound 7, NaH, DMF, rt.