Table 7.
Side effects of E2/NETA based on three randomized controlled trials
| Study | Endometrial: hyperplasia 12 months duration | Vasomotor symptom study: 3 months | Osteoporosis study: 24 months | |||
|---|---|---|---|---|---|---|
| Medication | 1.0 mg E2/0.5 mg NETA | 1.0 mg E2/0.5 mg NETA | 1.0 mg E2/0.5 mg NETA | |||
| Duration of medication | 12 months | 3 months | 24 months | |||
| Control group | Estradiol 1 mg | Placebo | Placebo | |||
| Side effect | E2/NETA | Estradiol | E2/NETA | Placebo | E2/NETA | Placebo |
| Headache | 16% | 5% | 3% | 3% | 6% | 4% |
| Gastroenteritis | 2% | 2% | 0% | 0% | 6% | 4% |
| Nausea | 3% | 5% | 10% | 0% | 11% | 0% |
| Breast pain | 24% | 10% | 21% | 0% | 17% | 8% |