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Contraindications to combination estradiol/progestin therapy
| Undiagnosed vaginal bleeding |
| Personal history of breast cancer |
| Known history of estrogen-dependent neoplasia |
| Active or history of deep venous thrombosis or pulmonary embolism |
| Active or history of arterial thrombotic event, including myocardial infarction or cerebral vascular accident |
| Liver disease |
| Hypersensitivity to medication |
| Pregnancy |
