Table 1.

Increased expression of the LMW slow TnT isoform in CMT1 but not CMT2 patients

	Number of Subjects	LMW Slow TnT Isoform, % total slow TnT
Control	12	29.7±7.1
CMT1	8	50.4±17.7*
CMT2	5	29.5±16.8†

Data are means ± SD. Data are summarized from a densitometry analysis of CT3 monoclonal antibody Western blots of single muscle fibers or frozen sections of muscle biopsies from Charcot-Marie-Tooth disease (CMT) type 1 (CMT1), CMT type 2 (CMT2), and control subjects, which demonstrated that the low-molecular-weight (LMW) slow troponin T (TnT) isoform had a significantly increased expression in CMT1 muscle compared with control or CMT2 muscles

^*P < 0.005.

In contrast, the expression pattern of high-molecular-weight and LMW slow TnT isoforms in CMT2 was not different from the control

^†P > 0.75.