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. 2008 Jun 27;295(3):H1351–H1368. doi: 10.1152/ajpheart.91526.2007

Fig. 5.

Fig. 5.

Serial evaluation of LV and RV function in mice with PAC. Top: LV fractional shortening (FS) was increased at 1 wk (w) in severe PS (primarily due to reduction in LV cavity size) and normal in mild and moderate PS. There was no significant difference between 1 and 4 wk in each group. Middle: RV outflow tract (RVOT) FS (in %) was decreased at 1 wk in severe PS and normal in mild and moderate PS. There was no further decline in RV FS in severe PS mice; however, RV FS began to decrease in mice with moderate PS by 3 wk. Bottom: RV wall velocity was decreased at 1 wk in severe PS and normal in mild and moderate PS. As with RVOT FS, mice with moderate PS showed a decrease in RV wall velocity by 3 wk. †P < 0.01 vs. 1 wk; *P < 0.01 vs. mild and moderate. Data obtained from 12 control mice before any surgical procedure are also shown.