Fig. 6.
Invasive hemodynamics. A: maximal change in pressure over time (dP/dtmax) increases immediately after PA banding (arrow). Tracing shows continuous measurements over 5 min. B: RV end-diastolic pressure (RVEDP) was significantly elevated at 6 h after banding and returned to baseline levels by 24 h. At 10 days (d), in mice with severe PS, RVEDP was significantly increased compared with that of pre-PAC (*P < 0.01) and compared with that of mild and moderate PS (*P < 0.01). Prebanding, n = 3 at 6 h, n = 3 at 24 h, n = 3 at 10 day; mild, n = 4 at 10 day; moderate, n = 5 at 10 day; severe, n = 5 at 10 day. C: there was a good correlation between RV free wall velocity obtained from TDI and dP/dtmax measured at various time intervals from 6 h to 10 day (r = 0.833; P < 0.0001; n = 23).