Table 1.
Effects of LAD ligation on cardiac contractile performance in WT and P2X4R Tg mice
| FS, % | LVDP, mmHg | +dP/dt, mmHg/s | |
|---|---|---|---|
| WT | |||
| Sham | 32.7±1.7 (8) | 130±2.6 (13) | 4,727±191 (13) |
| Ligated | 18.5±0.5 (33) | 106±2.3 (26) | 3,504±110 (26) |
| P2X4R Tg | |||
| Sham | 31.1±0.5 (9) | 141±2.5 (16) | 5,403±124 (16) |
| Ligated | 23.6±0.66 (24) | 117±1.9 (25) | 4,210±128 (25) |
Values are means ± SE (number of mice shown in parentheses). At 1 mo after left anterior descending coronary (LAD) ligation-induced myocardial infarction (MI), fractional shortening (FS) derived from echocardiography as well as left ventricular (LV) developed pressure (LVDP) and rate of contraction of LV pressure (+dP/dt) derived from isolated working heart preparation were obtained in wild-type (WT) and P2X4 receptor transgenic (P2X4R Tg) mice as described in methods. For all parameters, P < 0.05 in sham-operated vs. ligated animals in both WT and P2X4R Tg mice.